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Dosage schedule and frequency can have a significant influence
on adherence –in a study of 99 patients with UC in remission, when asked why the medications were not taken:3

forgot to take their medication

felt there were too many pills

did not think they needed so much medication

Once-daily (OD) PENTASA granules has higher adherence rates than divided dosing, reported at up to 97%4

Non-adherence can have significant effects on patients, with increased relapse rates and
generally worse clinical outcomes.1

An increase in relapse rates can have damaging effects on NHS budget, as the cost of managing patients rises:2


  • Lamb CA, et al. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. June 2019. Available at: bsgconsensus-guidelines-ibd-in-adults.html (accessed December 2019).
  • Ghosh N, et al. Frontline Gastroenterology. 2015;6:169–174.
  • Kane S, et al. Am J Med. 2003;114(1):39–43.
  • Iacucci M, et al. Can J Gastroenterol. 2010;24(2):127–133.

Job Code: UK-PA-2300006 - Date of preparation: November 2023


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