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About dinoprostone

Dinoprostone is a single application, removable, controlled-release vaginal delivery system containing 10 mg dinoprostone which is a prostaglandin E2. It is indicated for the initiation of cervical ripening in women from 37 completed weeks of gestation as part of the induction of labour process.1

When dinoprostone is inserted into the vagina, dinoprostone is released at a mean rate of approximately 0.3 mg/hour and drug release continues as long as the product is in situ in the vagina (for a period of up to 24 hours). The system is equipped with a withdrawal tape that facilitates convenient and easy removal when active labour begins or removal of the system is indicated.1

Dinoprostone Key Messages

Learn More

  1. Dinoprostone Summary of Product Characteristics. Available at: Accessed December 2023.
  2. Ferring Dinoprostone Data on File 2019.
  3. Kallkat R et al. Journal of Obstetrics and Gynaecology 2008;28:695-699.
  4. Calder A and Mackenzie A. Journal of Obstetrics and Gynaecology 1997;17(sup2):S53-S67.
  5. Westgate J and Williams J.A. Journal of Obstetrics and Gynaecology 1994;14:146-150.
  6. Kelly AJ et al. Cochrane Database of Syst 2014
  7. MacKenzie I and McKinlay E (1995). Paediatric follow-up study: Follow-up of infants delivered by spontaneous vaginal delivery, following prostaglandin E2 or oxytocin induction by caesarean section. In: Propess RS – A Clinical Review. Calder A, Keirse M and Mackenzie I (Eds). Euromed Communications Ltd. England.

Job Code: UK-RMMH-2300024 - Date of preparation: December 2023


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