Dinoprostone – The active substance is dinoprostone, more commonly known as Prostaglandin E2 (PGE2). Each vaginal delivery system contains 10 mg of dinoprostone which is released at approximately 0.3 mg per hour over 24 hours.
DINOPROSTONE INSERTION VIDEO
Watch this step-by-step video describing how to use dinoprostone correctly
Watch Now ➜INDUCTION PROCESS VIDEOS
These videos show a midwife explaining the induction of labour process to a woman who is about to be induced
Watch Now ➜DINOPROSTONE QUIZ
Test your knowledge and understanding of dinoprostone with our quiz
Take the Quiz ➜Dinoprostone Training and Resources
Dinoprostone is the first, single dose, retrievable vaginal insert for local, continuous and controlled release of dinoprostone in a retrievable and easy-to-use vaginal insert. Dinoprostone is indicated for the initiation of cervical ripening in patients at term (from 37 completed weeks of gestation).1
Dinoprostone is administered via a vaginal insert contained in a polyester pouch with a withdrawal tape. Dinoprostone releases dinoprostone at a constant and controlled rate.1
Where there is a need to terminate the drug administration, the dinoprostone vaginal insert can be easily retrieved, with the remaining dinoprostone in circulation rapidly cleared in 1-3 minutes.1
Dinoprostone Administration Video
Below is a short video showing the correct way to insert and remove dinoprostone.
A link to the prescribing information can be found here.
The Induction of Labour Process
Below videos show a midwife explaining the induction of labour process to a woman who is about to be induced.
Within this section you will find a wealth of video resources, aimed at educating you and your patient on the current induction of labour guidance, explaining what induction of labour is, why it is offered and methods available.
What is induction of labour and why is it offered?
What is membrane sweeping? - Here we explain a pre-induction method which is often used
What are prostaglandins? - Discover the role prostaglandins play in the softening of the cervix
What is artificial rupture of membranes? - Learn when this method of induction is recommended
What is oxytocin? - Understand the role of oxytocin augmentation during induction
What are the mechanical methods to induce labour? - Learn the types of mechanical methods used during induction
What if nothing happens? - Discover how long it can take before labour is established after an induction
Induction of Labour - Frequently Asked Questions (Full Video)
If you would like to test your knowledge and understanding of dinoprostone and how to administer dinoprostone, please take the short quiz below.
Dinoprostone Quiz
38 Weeks – Dinoprostone is licensed to be used after 37 completed weeks gestation.
In the freezer – Store in a freezer (-10ºC to -25°C). Store in the original container in order to protect from moisture. No thawing is required prior to use.
1-3 minutes – Dinoprostone has a half-life generally estimated as 1-3 minutes.
Immediately – Dinoprostone should be removed from the freezer just prior to the insertion. No thawing is required prior to use.
No – Do not use scissors or other sharp objects which may cut the retrieval system.
As high as possible – The vaginal delivery system should be inserted high into the posterior vaginal fornix and rotated so it sits transversely behind the posterior fornix
No – No attempt should be made to tuck the end of the tape into the vagina completely always leave a reasonable amount outside as this may make retrieval more difficult otherwise.
20-30 minutes – After insertion of dinoprostone, the patient should be recumbent for 20 minutes to 30 minutes. As dinoprostone will be released continuously over a period of 24 hours, it is important to monitor uterine contractions and foetal condition at frequent regular intervals.
- Onset of labour.
- Spontaneous rupture of the membranes or amniotomy.
- Any suggestion of uterine hyperstimulation or hypertonic uterine contractions.
- Evidence of foetal distress.
- Evidence of maternal systemic adverse dinoprostone effects such as nausea, vomiting, hypotension or tachycardia.
- At least 30 minutes prior to starting an intravenous infusion of oxytocin, as there is a much greater risk of hyperstimulation if the
dinoprostone source is not removed before administration of oxytocin. - 24 hours after insertion – The vaginal delivery system should be removed after 24 hours irrespective of whether cervical ripening has
been achieved.
All of the above – correct answer.
Learn More
- Dinoprostone Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/135.
