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Frequently asked questions about Fyremadel® 2

Here you will find answers to some of the questions your patients may ask you about Fyremadel®

Fyremadel® is a hormone treatment that suppresses your body’s naturally-occurring egg-producing hormones.


In women undergoing assisted reproduction techniques, including in vitro fertilisation (IVF) and other methods, occasionally ovulation may occur too early causing a significant reduction in the chance of getting pregnant. Fyremadel is used to prevent the premature LH surge that might cause such a premature release of egg cells.

Women who are undergoing assisted reproduction techniques, such as IVF.

You should not use Fyremadel® if you are: allergic to any of its ingredients such as ganirelix (or other excipients listed in the patient information leaflet); hypersensitive to gonadotrophin releasing hormones; pregnant or breast feeding or have moderate or severe kidney or liver disease.  Fyremadel® treatment is not advised in women with severe allergic conditions. You should not use Fyremadel® if you have a latex allergy as the needle cover contains dry natural rubber/latex which comes into contact with the needle and may cause allergic reactions.

Please consult with your doctor if you are taking, have recently taken or might take any other medicines to make sure the combination is safe.

Fyremadel® is essentially sodium free, containing less than 1 mmol sodium (23mg) per injection.

You must inject yourself with the pre-filled Fyremadel® syringes; your doctor will show you how and when to use it.

Follow the link below for more detailed information on our ‘How to Inject’ guide.


You should contact your doctor if you take too much Fyremadel®.

If you realise that you forgot a dose, administer it as soon as possible.

Do not inject a double dose to make up for a forgotten dose. If you are more than 6 hours late (so the time between two injections is longer than 30 hours) administer the dose as soon as possible and contact your doctor for further advice.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Very Common: You may have temporary redness or swelling around the injection site.

Uncommon: Some people generally feel unwell or experience headaches or, nausea.

Very rarely, people may have an allergic reaction to the medicine including rash, facial swelling, difficulty with breathing and/or swallowing (anaphylaxis) or worsening of a pre-existing eczema.

You should also be aware the follicle stimulating hormone (FSH) that is taken in conjunction with Fyremadel® can cause some other serious side effects. Among them is Ovarian Hyperstimulation Syndrome (OHSS) where your ovaries overreact to the fertility medicine you are taking and can cause abdominal swelling, bloating, abdominal pain, nausea, vomiting, diarrhoea or shortness of breath. OHSS is not a listed side effect of Fyremadel.

  1. Fyremadel Summary of Product Characteristics. Fyremadel 0.25 mg/0.5 ml solution for injection in pre-filled syringe. Available: (last accessed on September 2023).
  2. Patient Information Leaflet Fyremadel 0.25 mg/0.5 ml solution for injection in pre-filled syringe. Available: (last accessed September 2023).

Job Code: UK-FYR-2300004 - Date of preparation: September 2023


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