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A step-by-step guide which you may find helpful when demonstrating how to use Fyremadel® with your patients.



How to inject Fyremadel® using the pre-filled syringes2

Fyremadel® is supplied in pre-filled syringes that contain one daily dose. You should only use a Fyremadel® pre-filled syringe once, after which it should be disposed of by placing into a sharps container.

  • The contents of the pre-filled syringe should be injected slowly, just under the skin (subcutaneous), preferably in the upper leg.
  • Each time you inject yourself, it is recommended that you select a different injection site to the previous site used. For detailed injection technique in all eligible body sites, you are advised to contact the prescribing physician.


  • Wash your hands thoroughly with soap and water.


  • Swab the injection site with a disinfectant (for example alcohol) to remove any surface bacteria.
  • Clean about 5cm (two inches) around the point where the needle will go in and let the disinfectant dry for at least one minute before proceeding.
  • Inspect the solution before use. Do not use if the solution contains particles or is not clear. Do not mix Fyremadel® with any other medicines.


  • Remove the needle cover


  • Pinch a large area of skin between finger and thumb


  • Insert the needle at the base of the pinched-up skin at an angle of 45° to the skin’s surface.


  • To check the needle is in the correct position, gently draw back the plunger. If any blood appears, the needle tip has penetrated a blood vessel.
  • If this happens, do not continue with the injection of Fyremadel®. Remove the syringe, cover the injection site with a swab containing disinfectant and apply pressure; bleeding should stop in a minute or two.
  • You must also dispose of the syringe and start again with a new one.


  • Once the needle is correctly positioned, depress the plunger slowly and steadily, so the solution is correctly injected.


  • Pull the syringe out quickly and apply pressure to the site with a disinfectant swab.


Report any side effects to your fertility clinic or pharmacist. This includes any possible side effects not listed in the package leaflets. Patients can also report side effects directly via the Yellow Card Scheme at

Adverse events should also be reported to Ferring Pharmaceuticals Ltd.
Tel: 0800 111 4126 Email:

Fyremadel is a Sun Pharma product and adverse events should also be reported to them. Sun Pharma medical information email: or call their Medical Information Direct Line 0208 848 5052.

By reporting side effects patients can help provide more information on the safety of these medicines.

  1. Fyremadel Summary of Product Characteristics. Fyremadel 0.25 mg/0.5 ml solution for injection in pre-filled syringe. Available: (last accessed September 2023).
  2. Fyremadel Patient Information Leaflet Fyremadel 0.25 mg/0.5 ml solution for injection in pre-filled syringe. Available: (last accessed September 2023).

Job Code: UK-FYR-2300004 - Date of preparation: September 2023


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