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Trial type: retrospective cohort study

Participants: 544 women undergoing IVF at a tertiary referral infertility centre

Primary outcome: ongoing pregnancy rate

Secondary outcomes: rates of clinical pregnancy and pregnancy loss (chemical and miscarriage), serum progesterone levels during the luteal phase and early pregnancy

Comparator agents: Endometrin® (100 mg vaginal progesterone tablets; marketed as Lutigest® in the UK) (n = 145) and 100mg intramuscular progesterone injections (n = 399)

Protocollong GnRH agonist



Ongoing pregnancy rate: Lutigest® not statistically different to IM progesterone [odds ratio (95% confidence interval): 1.0675 (0.7587-1.5020)]

Rates of total pregnancy lossLutigest® not statistically different to IM progesterone [odds ratio (95% confidence interval): 1.0775 (0.7383-1.5727)]

Mean serum progesterone levels during luteal phaseLutigest® not statistically different to IM progesterone [0.8 +/- 0.4 (0.2-2.6) and 1.0 +/- 0.25 (0.4-1.0)]

Mean serum progesterone levels during early pregnancyDuring early pregnancy, serum progesterone levels were statistically significantly higher in the Lutigest® group on mean days (after oocyte retrieval) of 19-22, 23-26, and 27 days to 12 weeks of gestation.


Mean serum progesterone levels following oocyte retrieval (pregnant patients)



Luteal support with Lutigest® was associated with treatment outcomes that were no different from those associated with IM progesterone.



  1. Lutigest Summary of Product Characteristics. Lutigest 100 mg vaginal tablets Available: (last accessed on 01-September-2023).
  2. Mitwally MF et al. Fertil Steril 2010; 93: 554-569.

Job Code: UK-LUG-2300004 - Date of preparation: September 2023


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